Behavioral deficits and cholinergic pathway abnormalities in male Sanfilippo B mice
نویسندگان
چکیده
منابع مشابه
Development of Sensory, Motor and Behavioral Deficits in the Murine Model of Sanfilippo Syndrome Type B
BACKGROUND Mucopolysaccharidosis (MPS) IIIB (Sanfilippo Syndrome type B) is caused by a deficiency in the lysosomal enzyme N-acetyl-glucosaminidase (Naglu). Children with MPS IIIB develop disturbances of sleep, activity levels, coordination, vision, hearing, and mental functioning culminating in early death. The murine model of MPS IIIB demonstrates lysosomal distention in multiple tissues, a s...
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ژورنال
عنوان ژورنال: Behavioural Brain Research
سال: 2016
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2016.06.023